Is UroFresh worth trying?
Yes, if you want daily urinary tract support with a label you can read line by line. UroFresh by Simple Promise lists every dose: 1,000 mg of D-mannose, 150 mg of cranberry juice powder, and 100 mg each of hibiscus and dandelion extract. A 365-day money-back guarantee covers every order. An active UTI still needs your doctor.
What is UroFresh by Simple Promise, and who is it for?
UroFresh is a dietary supplement in capsule form, sold by Simple Promise, for women who want everyday urinary tract support. You take two capsules once a day, and each bottle lasts 30 days. Simple Promise lists a contact address in Camas, Washington, and a toll-free phone line on its official page.
If you're over 40 and tired of UTIs that keep coming back, I wrote this with you in mind. I've lived through recurrent UTIs myself, with the urgency and leaks that came with them, and I know how much it helps to have clear answers before you try something new.
What's inside UroFresh?
Each two-capsule serving holds 1,000 mg of D-mannose, 150 mg of cranberry juice powder, 100 mg of hibiscus extract and 100 mg of dandelion extract. Every amount is printed on the Supplement Facts panel, so there's no proprietary blend to guess at. The capsule is vegetable-based, and the ingredient list is short and easy to read.
| Label item | What it says |
|---|---|
| Serving size | 2 capsules |
| Servings per container | 30 |
| D-Mannose | 1,000 mg |
| Cranberry Juice Powder (Vaccinium macrocarpon, fruit) | 150 mg |
| Hibiscus Extract (Hibiscus sabdariffa, flower) | 100 mg |
| Dandelion Extract (Taraxacum officinale) | 100 mg |
| Other ingredients | Vegetable capsule (cellulose). The Supplement Facts image also lists silicon dioxide. |
| % Daily Value | Not established |
| Suggested use | 2 capsules once a day, 20 to 30 minutes before a meal, with 8 oz of water |
How does UroFresh work?
The idea is to make it harder for bacteria to cling to the bladder wall, so they leave the body when you pee. Cranberry's natural compounds, called proanthocyanidins or PACs, and D-mannose, a simple sugar, are both studied for this anti-sticking effect on E. coli. Hibiscus and dandelion round out the formula with plant extracts.
The label's suggestion to take the capsules with a full glass of water fits a habit doctors already encourage. The American Urological Association (AUA) guideline notes that women with recurrent UTIs who drink less than 1.5 liters (50 ounces) a day may be offered increased water intake as part of prevention.
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What does the research say about UroFresh's ingredients?
Cranberry is the best-supported ingredient in UroFresh. A 2023 Cochrane review of 50 studies found that cranberry products lowered the risk of UTIs by about 26% in women with recurrent infections. The other three ingredients have weaker support so far, and the table below shows where each one stands.
| Ingredient | In UroFresh, per day | What was studied | Main result |
|---|---|---|---|
| Cranberry | 150 mg of juice powder | Cochrane review, 2023: 50 studies of cranberry products in many forms and doses | Lower UTI risk in women with recurrent UTIs |
| Cranberry | 150 mg of juice powder | Stonehouse, 2025: 500 mg a day of whole cranberry fruit powder, 150 women with recurrent UTIs, 6 months | 52% lower risk of a culture-confirmed UTI than placebo (study sponsored by a supplement company) |
| D-mannose | 1,000 mg | Hayward, 2024: 2 g a day of D-mannose powder, women with recurrent UTIs, 6 months | Results similar to placebo |
| Hibiscus | 100 mg of extract | Two early studies: a hibiscus drink in long-term care residents with urinary catheters (2016) and a combination product taken by 100 women after a bladder test (2019) | Fewer UTIs observed with the drink; neither study had a placebo group |
| Dandelion | 100 mg of extract | Clare, 2009: a leaf extract taken for one day by 17 volunteers | More frequent urination after the first dose; UTIs were not studied |
How long should you take it?
Think in months. The cranberry and D-mannose trials above each ran for six months, because prevention shows up as fewer infections over time. Taking your two capsules every day for a few months is a fair way to see how UroFresh fits your routine, and the 365-day guarantee gives you plenty of room to do that.
Where does the research stand?
Research on non-antibiotic prevention is moving in a helpful direction, and cranberry is the bright spot: the AUA guideline says clinicians should offer it as an option for women with recurrent UTIs. A few points keep expectations realistic: in the largest D-mannose trial so far (JAMA Internal Medicine, 2024, 598 women, 2 grams a day), D-mannose did no better than placebo, the guideline adds that D-mannose alone may not be effective, the best cranberry dose is still unknown, and UroFresh's amounts are lower than the ones used in these trials. That's why I see UroFresh as daily support with cranberry in the mix, taken alongside your doctor's care. Our guide to D-mannose vs cranberry for UTI walks through these studies in more detail.
Can UroFresh treat a UTI you already have?
No. UroFresh is a dietary supplement for daily support, and it isn't a treatment for an infection you already have. The NIH's National Center for Complementary and Integrative Health (NCCIH) says in its cranberry fact sheet that cranberry isn't recommended as a treatment for existing UTIs in any population.
A 2022 Cochrane review likewise found little to no evidence that D-mannose treats UTIs. Burning when you pee, fever, pain in your back or side, or blood in your urine are reasons to call your doctor. The AUA guideline recommends a urine test and culture with each symptomatic episode, so the right treatment can start quickly.
Is UroFresh a good fit after 40 or after menopause?
It can be, as one part of a bigger plan for your urinary health. For women in perimenopause or after menopause who have recurrent UTIs, the AUA guideline recommends vaginal estrogen therapy when there's no reason to avoid it, and it lists cranberry as an option to offer. A daily formula like UroFresh can sit alongside that plan.
If leaks or urgency are part of your picture too, as they were for me, our guide to pelvic floor exercises for women over 50 explains what the research shows. And if you're also weighing a probiotic, our review of a women's probiotic reads its label the same way.
What are the pros and cons of UroFresh?
What I like most is the open label: every dose is listed, the guarantee runs a full 365 days, and the order is a one-time purchase. A few points are worth knowing before you order, and I've kept them short so you can weigh them against everything the formula has going for it.
Pros
- Every ingredient amount is on the label, with no proprietary blend.
- Includes cranberry, the ingredient with the strongest research for preventing repeat UTIs.
- Two capsules once a day, easy to fit into any routine.
- Short ingredient list in a vegetable capsule.
- 365-day money-back guarantee that, per the official page, applies even to empty bottles.
- Free US shipping on all three packages.
- One-time purchase, according to the official page (October 2026).
- The price drops to $33 a bottle with the largest package.
Cons
- The label gives cranberry by weight (150 mg of juice powder) rather than by PAC content.
- The amounts of cranberry and D-mannose are lower than those used in the main trials, and cranberry is where the stronger evidence sits.
- Its ingredients have been studied; the finished formula doesn't have its own published trial yet.
How we scored it
| Criterion | Score | Why |
|---|---|---|
| Label transparency | 5 / 5 | All four ingredient amounts are printed on the Supplement Facts panel |
| Buying terms | 5 / 5 | 365-day money-back guarantee, free US shipping, one-time packages |
| Ease of use | 4.5 / 5 | Two capsules once a day, short ingredient list, vegetable capsule |
| Safety profile | 3.5 / 5 | Side effects reported for cranberry and D-mannose in studies are few and mild; with four plant-based ingredients, a quick medicine check with your pharmacist is wise |
| Research fit | 2.5 / 5 | Cranberry, the best-supported ingredient, is in the formula; the research section shows how the amounts compare |
| Overall | 4.1 / 5 | A good option for everyday support |
Who is UroFresh best for?
It suits women who get repeat UTIs and want simple, everyday urinary tract support between infections, alongside their doctor's care. It's also a comfortable choice if you like knowing exactly what you're taking and want a long refund window. If you have symptoms right now, please see your doctor first.
A good fit if you
- Have had repeat UTIs and want daily support alongside your doctor's plan.
- Prefer a label that shows every dose.
- Are in perimenopause or menopause and looking at non-antibiotic options with your doctor.
- Are ready to take it consistently for a few months.
Better to wait if you
- Need relief from a UTI right now (that calls for a doctor, not a supplement).
- Are pregnant or breastfeeding, unless your doctor agrees.
- Take a blood thinner, diabetes medicine or water pills and haven't checked with your doctor or pharmacist yet.
Talk to your doctor first if…
- You have symptoms of a UTI now, such as burning, urgency or needing to go often. A supplement isn't a treatment; you may need a urine test and antibiotics.
- You have a fever, chills, or pain in your back or side. The AUA guideline lists fever and flank pain as signs the infection may have moved beyond the bladder. Get care the same day.
- You see blood in your urine.
- Your UTIs keep coming back. The AUA guideline defines recurrent UTI as two episodes within six months, and it deserves a proper workup.
- You're pregnant or breastfeeding. The UroFresh label says to consult your healthcare provider first.
- You take warfarin or another blood thinner, diabetes medicine or water pills. The NCCIH notes possible interactions with cranberry or dandelion.
- You're allergic to ragweed, chrysanthemums, marigolds or daisies. The NCCIH says the evidence is mixed on whether dandelion can trigger a reaction in people sensitive to these related plants.
- You have a medical condition or take prescription medicines, so your doctor or pharmacist can advise you.
How much does UroFresh cost?
As of October 2026, UroFresh costs $49 for one bottle, $39 per bottle in the 3-bottle package ($117) and $33 per bottle in the 6-bottle package ($198). US shipping is free on all three, each order is a one-time purchase according to the official page, and your cart shows the final total before you pay.
Prices as of October 3, 2026, from the official order page; daily cost is our arithmetic (30 servings per bottle). Prices can change, and your cart shows the final total, including any tax, so confirm it there before you pay.
Which package should you choose?
For a first order, I'd go with the 3-bottle package: prevention is judged over months, the price drops by $10 a bottle, and the 365-day guarantee covers the whole supply. If you'd rather start small, one bottle works too. And if you already know you'll stay consistent, the 6-bottle package brings the price down to $33 a bottle. Either way, keep your order confirmation email handy.
How does the UroFresh 365-day guarantee work?
You have 365 days to ask for a full refund, and the official page says it applies even if the bottles are empty. To use it, you contact Simple Promise customer service and send the bottles back, and the refund is issued once the returns team receives them. Here is the process, step by step.
- Contact customer service within 365 days. The official page says to email the team; Simple Promise lists support@mysimplepromise.com and the toll-free number 1-800-259-9522.
- Send the bottles back, used or not. The official page says you can return them even if they're empty.
- Allow time for the refund. According to the brand's store FAQ, the refund is processed once the returns department receives the package, which can take up to 2 weeks, plus 10 to 14 business days for your bank or card issuer.
When you write, ask for the return address and whether return postage is covered, since the pages I read don't go into that detail. If you ordered a multi-bottle package, the official page says the bonus videos are yours to keep.
Frequently asked questions
Does UroFresh have side effects?
Its main ingredients are usually well tolerated. In a 2022 Cochrane review, D-mannose side effects were few and none were serious (mostly diarrhea and vaginal burning), though the review notes they were poorly reported. The NIH's NCCIH says cranberry is generally thought to be safe, though very large amounts can cause stomach upset. Ask your doctor if you take medicines.
Will UroFresh make me pee more often?
It might, a little. Dandelion has a long history of traditional use as a diuretic, and in a small 2009 pilot study, 17 volunteers who took a dandelion leaf extract urinated more often in the hours after the first dose. That study used a different extract and amount than UroFresh, so your experience may differ.
Can I take UroFresh with antibiotics or other medicines?
Ask your doctor or pharmacist first. The UroFresh label advises checking with a healthcare provider if you take medications. The NCCIH notes possible interactions between cranberry and the blood thinner warfarin, and between dandelion and diabetes medicines, blood thinners and water pills. If you're prescribed an antibiotic, finish it exactly as directed.
Does UroFresh help with bladder leaks or urgency?
UroFresh is formulated for urinary tract health, and the studies in this review looked at infections rather than leaks. The 3-bottle and 6-bottle packages do come with bonus pelvic floor exercise videos, according to the official page. If leaks or urgency are your main concern, they deserve their own conversation with your doctor.
Is UroFresh a subscription?
No. The official page describes every package as a one-time purchase and says you won't be billed again (checked October 2026). As with any online order, it's a good habit to review your cart total before you pay and to keep your confirmation email, which also helps if you ever use the 365-day guarantee.
Conclusion
Our final verdict on UroFresh
4.1 / 5 · A good option for everyday support
UroFresh by Simple Promise is a daily formula with an open label, cranberry in the mix and a full-year refund window. If you want everyday urinary tract support between infections, it's an easy one to try. It isn't a UTI treatment, so keep your doctor in the loop and let the 365-day guarantee take the pressure off your first order.
Try UroFresh with the 365-day guarantee✓ 365-day money-back guarantee stated by the seller · Free US shipping on all packages
Sources
- Simple Promise. UroFresh product page on the brand's official store (Supplement Facts panel, suggested use), store FAQ and refund policy; official UroFresh sales page and order page (packages, prices, shipping, billing, guarantee). Checked October 3, 2026.
- Williams G, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews. 2023;4:CD001321. doi:10.1002/14651858.CD001321.pub6. PMID 37068952.
- Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD. Whole cranberry fruit powder supplement reduces the incidence of culture-confirmed urinary tract infections in females with a history of recurrent urinary tract infection: a 6-month multicenter, randomized, double-blind, placebo-controlled trial. American Journal of Clinical Nutrition. 2025;121(4):932-941. doi:10.1016/j.ajcnut.2025.01.022. PMID 39863114.
- Hayward G, Mort S, Hay AD, et al. d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial. JAMA Internal Medicine. 2024;184(6):619-628. doi:10.1001/jamainternmed.2024.0264. PMID 38587819.
- Cooper TE, Teng C, Howell M, Teixeira-Pinto A, Jaure A, Wong G. D-mannose for preventing and treating urinary tract infections. Cochrane Database of Systematic Reviews. 2022;8:CD013608. doi:10.1002/14651858.CD013608.pub2. PMID 36041061.
- Chou ST, et al. Exploring the effect and mechanism of Hibiscus sabdariffa on urinary tract infection and experimental renal inflammation. Journal of Ethnopharmacology. 2016;194:617-625. PMID 27773797.
- Milandri R, et al. Effectiveness of D-mannose, Hibiscus sabdariffa and Lactobacillus plantarum therapy in prevention of infectious events following urodynamic study. Urologia. 2019;86(3):122-125. PMID 30208764.
- Clare BA, Conroy RS, Spelman K. The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day. Journal of Alternative and Complementary Medicine. 2009;15(8):929-934. PMID 19678785.
- American Urological Association. Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline. Published 2019, reviewed 2022, amended 2025. Checked October 3, 2026.
- National Center for Complementary and Integrative Health (NCCIH), U.S. National Institutes of Health. Cranberry: Usefulness and Safety. Last updated November 2024. Linked in the text above.
- National Center for Complementary and Integrative Health (NCCIH), U.S. National Institutes of Health. Dandelion: Usefulness and Safety. Last updated November 2024. Checked October 3, 2026.
Claire Donovan
I'm Claire Donovan, a 47-year-old woman who became much more interested in women's health after experiencing some of my own challenges with pelvic and urinary health.
I'm not a doctor or healthcare professional. I'm simply someone who has spent years researching these subjects, comparing information, reading scientific research, and looking for reliable answers from trusted and official sources.
My goal is simple: to make reliable information easier to understand and help women feel more informed about their own health. More about me.
Last updated: . Prices, packages and label details were checked on this date.
How this review was made: it's based on the product label, the official order page and published research.
Affiliate disclosure: we may earn a commission if you buy through the order links on this page, at no extra cost to you. Full disclosure.
Medical note: this review is general information and isn't medical advice. Medical disclaimer.